Precision Signals
Precision Signals
Podcast Description
Precision Signals is a podcast from the CEO Roundtable on Cancer about decoding biomedical progress: what’s real, what matters, and what’s next. We talk with scientists, regulators, investors, and builders operating across the messy interface of research, healthcare, and policy. Some are moving the system from within; others are reshaping it from the outside. All of them bring signal in a world crowded with noise.
Podcast Insights
Content Themes
The podcast covers critical topics related to biomedical research, healthcare systems, and regulatory frameworks. Episodes like 'The Mission is the Boss' focus on the challenges in clinical trials, discussing the journey of innovators like Dr. Michelle Longmire, while another episode, 'AI in Oncology: Hype, Evidence, and the Threshold of Clinical Trust', dives into the critical necessity of randomized trials for AI adoption in cancer care, illustrating the intricate balance between innovation and practical application.

Precision Signals is a podcast from the CEO Roundtable on Cancer about decoding biomedical progress: what’s real, what matters, and what’s next. We talk with scientists, regulators, investors, and builders operating across the messy interface of research, healthcare, and policy. Some are moving the system from within; others are reshaping it from the outside. All of them bring signal in a world crowded with noise.
Dr. Karen Knudsen, CEO of the Parker Institute for Cancer Immunotherapy (PICI), joins Dr. Sean Khozin to dissect the science and business of curing cancer. From her upbringing as a self-described “nomad” and “army brat” to leading the American Cancer Society, Karen shares her journey from the lab bench to the boardroom.
In this episode, we explore the Parker Institute’s unique model of “venture philanthropy.” Karen explains how PICI uses shared intellectual property to de-risk early-stage science and spin out venture-ready companies like Dispatch and Orbital Therapeutics. We also discuss the challenges of modernizing a historic non-profit with “no product” to sell , the intersection of AI and biomarkers with companies like ArteraAI , and PICI’s massive data project, “Radiohead”.
Karen is candid about her leadership philosophy: she is not a “keep the trains running” executive, but a leader built for transformation.

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