Dr. Sandeep “Bob” Datta is a Professor of Neurobiology at Harvard Medical School whose work blends neuroscience, behavior, and machine learning to decode how the brain controls behavior. Here he sits down with Anirvan Ghosh to discuss the fascinating series of discoveries that led to the identification of MS4A6D as a critical protein that regulates the spread of Tau pathology, a major driver of Alzheimer's disease. He goes on to candidly discuss how recent decisions on federal research funding at Harvard led to a sudden termination of his research grants, and how that is threatening promising research on a devastating disease that affects millions of people around the globe.