Hack You
Hack You
Podcast Description
Co-hosted by Mike Thurston and Vadim Fedotov, Hack You is a space for real conversations with world-class experts on what you can do to optimise your health and performance.
Podcast Insights
Content Themes
The podcast focuses on various health optimization themes such as hormone balance, mitochondrial health, and strength training. Episodes address topics like the smart use of peptides for recovery, practical hormone management strategies, and the fundamentals of muscle growth tailored to listener goals.
Co-hosted by Mike Thurston and Vadim Fedotov, Hack You is a space for real conversations with world-class experts on what you can do to optimise your health and performance.
Ryan Smith is the founder of TruDiagnostic and a leading voice in biological ageing, hormone science, and health optimisation. In this episode, we get into the real drivers of long-term vitality, why most people are tracking the wrong markers, how to train and supplement based on your biological age, and what bloodwork actually matters.
We also touch on the emerging field of methylation clocks and how to think about reversing your true age, not just your appearance. Whether you’re already deep into your health stack or just starting to explore it, this is a sharp, grounded conversation that cuts through the noise.
00:00 Introduction
02:10 Epigenetics, biological age, and the future of health
02:38 Leaving medical school to build a peptide pharmacy
04:34 Discovering biological clocks as better health markers
06:13 How epigenetic testing works with one drop of blood
09:45 Current limits of personalised lifestyle recommendations
11:25 Predicting biomarkers and disease risk from methylation
15:08 Best diet for longevity across all tested options
17:49 Measuring biological age of 11 different organ systems
21:33 Tadalafil’s surprising longevity benefits and gender split
24:43 Social bonds, stress, and psychological health matter
26:01 Supplements ranked for biological age improvement
29:49 Stronger interventions like SGLT2 inhibitors and fast mimetics
33:16 Data on fasting duration and calorie restriction
37:00 Best longevity peptides and promising new compounds
38:59 Therapeutic plasma exchange and young blood potential
42:32 Sleep, sex, and movement as core health levers
44:51 Psychedelics and ketamine showing anti-aging promise
48:23 When lifestyle changes backfire and how to adjust
50:19 How to start testing and find a reliable provider
DISCLAIMER
Nothing shared on this podcast is a substitute for professional medical guidance. Please consult a healthcare professional before making any health or lifestyle changes.
Hack You Media
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Bioniq: https://www.bioniq.com/
→ Follow Ryan
Website: https://www.trudiagnostic.com/
Disclaimer
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