In this episode, Joan Chen, MD, of the University of Michigan, and Ofer Fass, MD, of Northwestern Medicine, review the latest developments in eosinophilic esophagitis (EoE) diagnosis, treatment, and long-term management. The discussion explores emerging EoE therapies, including the investigational, locally administered corticosteroid EP-104GI, as well as new research evaluating dupilumab in patients with severe fibrostenotic disease, esophageal narrowing, and treatment-refractory EoE. Drs. Chen and Fass also examine the rising incidence and prevalence of eosinophilic esophagitis, highlighting recent epidemiologic data and the need for greater awareness among referring clinicians. Additional topics include current biopsy recommendations, transnasal endoscopy, the potential role of peripheral blood eosinophil counts as a less invasive diagnostic signal, and the importance of monitoring histologic, endoscopic, and symptomatic disease activity. Looking ahead, the experts discuss personalized EoE care, multidisciplinary collaboration, shared decision-making, and emerging biologic therapies that may provide additional options for patients who do not respond to existing treatments. This educational podcast offers practical insights for healthcare professionals seeking to stay informed about evolving EoE research and the future of eosinophilic esophagitis management.