At GI ReConnect, Dr. Dakesh Patel and registered dietitian Kate Scarlata dive into the overlooked role of carbohydrate maldigestion, malabsorption, and intolerance in patients experiencing common gastrointestinal symptoms such as gas, bloating, abdominal pain, and diarrhea. Drawing on their recent publication in the American Journal of Gastroenterology, they break down how deficiencies in enzymes like lactase, sucrase, maltase, and isomaltase can disrupt carbohydrate breakdown and trigger IBS-like symptoms. The discussion explores the distinctions between maldigestion, malabsorption, and intolerance, the influence of gut microbiota, and the importance of considering carbohydrate intolerance as a trigger for IBS. They also highlight emerging diagnostic approaches, the role of diet—including low-FODMAP strategies—and enzyme replacement therapies to improve patient outcomes while maintaining nutritional balance. Whether you’re a gastroenterologist, dietitian, or patient seeking to understand the science behind carbohydrate intolerance, this session offers practical insights into managing digestive health.