Bacterial genomics is the focus of our deep dive today, especially how it plays a crucial role in tackling antimicrobial resistance. Ashrita R, a student at Detroit Country Day School, is the creator of Back to Bacteria, a puppet show that guides us through the fascinating world of bacteria and DNA. The episode features special guests, Pinky the Antibiotic and Helix the DNA segment, who share insights on how antibiotic resistance develops and spreads, as well as how genomics can help in understanding and combating these issues. They also discuss a groundbreaking study that utilized bacterial genomics to investigate treatment failures in Staphylococcus aureus infections, shedding light on the adaptive mutations that contribute to antibiotic resistance. By the end of the show, Ashrita hopes you gain a greater understanding of bacterial genomics and its potential to inform personalized medicine, helping to ensure better outcomes in the fight against bacterial infections.