Heart2Heart Talk with Mary Burrell
Heart2Heart Talk with Mary Burrell
Podcast Description
I’m Mary Burrell, a hospice survivor and one of the first patients in the U.S. to receive a transcatheter tricuspid valve through an early feasibility clinical trial. A procedure still in testing and not yet FDA-approved. Now, I’m using that chance to speak up for patients, caregivers, and anyone trying to navigate a healthcare system without a clear roadmap
Heart 2 Heart Talk is where real conversations happen. We talk about the emotional, physical, and practical sides of survival. From clinical innovation to caregiver burnout, from broken systems
Podcast Insights
Content Themes
The podcast explores various themes including clinical innovation, caregiver burnout, and patient advocacy, with episodes that feature personal stories like Mary’s journey through hospice and clinical trials, and discussions on the emotions involved in caregiving, highlighting individual narratives and systemic healthcare challenges.

Heart2Heart Talk is a place for honest conversations about living with heart valve disease. Hosted by hospice survivor and patient Mary Burrell, we bridge the gap between clinical data and the human experience.
Join patients, caregivers, and experts for raw conversations on symptoms, clinical trials, and the fears no one whispers out loud. From navigating doctors to finding your voice, we share the stories behind the diagnosis.
Where we speak from the heart, for the heart.
Episode: #5
Guest: Dr. Raj Makkar
Topics: Transcatheter Therapy | Heart Valve Repair | Heart Valve Replacement
When you’ve been told you’re 'too complex' or 'too high-risk' for surgery, it can feel like the door has been slammed shut. Today, we’re opening that door back up.”
For decades, fixing a heart valve meant open-heart surgery—a high-risk prospect for survivors whose bodies have already been through the fires of radiation or chemotherapy. But cardiac care has been transformed. In this episode, host Mary Burrell is joined by Dr. Raj Makkar, a world-renowned expert at the Smidt Heart Institute at Cedars-Sinai, to discuss the evolution of transcatheter valve therapies.
With a career defined by over 5,000 procedures, Dr. Makkar is at the forefront of repairing and replacing the heart’s ”plumbing” from the inside out. We explore how these minimally invasive techniques provide a safer, faster path to recovery for those whose medical histories make traditional surgery a challenge.
Strategic Insights from This Episode:
- The Power of Minimally Invasive Care:Why a catheter-based repair or replacement is often the safest choice for a survivor with ”fragile” or radiation-scarred anatomy.
- Faster Recovery, More Time: How moving away from ”the zipper scar” allows survivors to get back to their lives without the months-long recovery of traditional surgery.
- Rejecting the ”Too Complex” Label: Dr. Makkar’s advice for patients who have been sidelined by the medical system and told there is no hope for a fix.
- The Specialist Connection: How to ensure your cardiologist understands the link between your cancer history and your valve health so nothing gets missed.
If the system has told you ”no,” this conversation is about finding the specialist who can say ”yes.”
Tune in to shift the narrative from fragmented survival to strategic advocacy. Let’s build the bridge the system forgot.
Clinical Resources:
The Structural Blueprint: Cedars-Sinai: Heart Valve Disease Guide — A clear explanation of heart valve mechanics and how to identify the signs of structural failure.
The Science of Survival:A deep-dive into how past cancer treatments ”reprogram” the heart’s metabolism and the dormant cellular changes—like oxidative stress and fibrosis—that can lead to valve failure decades late
Explore the Whole Picture:
Learn more about our Guest: Dr. Raj Makkar
Visit our Website: https://www.maryburrell.com
Connect with Us: [email protected]
Subscribe to the Show: Heart2Heart Talk
Championing the whole heart—yours, ours and theirs.
#Heart2HeartTalk ##HeartValveRepair #HeartValveReplacement #CardioOncology #StructuralHeart #PatientAdvocacy #CedarsSinai

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