The Gold Standard with Mark S. Gold, MD
The Gold Standard with Mark S. Gold, MD
Podcast Description
Join renowned psychiatrist and addiction expert Dr. Mark S. Gold as he hosts THE GOLD STANDARD, an insightful and dynamic video series featuring in-depth interviews with the world’s leading experts in psychiatry, addiction medicine, and cutting-edge healthcare. In each episode, Dr. Gold taps into the minds of thought leaders, groundbreaking researchers, and clinical pioneers, delving into the most pressing issues facing mental health and addiction treatment today.
Podcast Insights
Content Themes
The show focuses on mental health and addiction treatment, addressing essential topics like addiction medicine's evolution, the public health implications of cannabis use, and culturally informed mental health care, exemplified by episodes such as 'Addiction Medicine: From the Summer of Love to the Fentanyl Crisis' and 'Culturally Informed Mental Health Care.'

Join renowned psychiatrist and addiction expert Dr. Mark S. Gold as he hosts THE GOLD STANDARD, an insightful and dynamic video series featuring in-depth interviews with the world’s leading experts in psychiatry, addiction medicine, and cutting-edge healthcare. In each episode, Dr. Gold taps into the minds of thought leaders, groundbreaking researchers, and clinical pioneers, delving into the most pressing issues facing mental health and addiction treatment today.
In this landmark episode of The Gold Standard, Dr. Mark Gold speaks with Dr. John Krystal, Chair of Psychiatry at Yale School of Medicine and the longtime Editor‑in‑Chief of Biological Psychiatry.
This in‑depth conversation traces the scientific origins of ketamine’s rapid antidepressant effects, the unique neuroscience culture at Yale, and how mechanism‑driven psychiatry is reshaping treatment for depression, PTSD, addiction, and beyond.
This episode goes far beyond ketamine alone. Dr. Krystal reflects on how psychiatry moved from monoamine theories toward circuit‑based neuroscience, and why depression, trauma, and addiction require fundamentally different ways of thinking.

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