When Claude Mythos dropped, the question wasn’t whether AI could find vulnerabilities, it was whether defenders would move faster than the attackers who were already racing toward the same capability. The gap between those two timelines is shrinking faster than most organizations want to admit, and the teams still betting on the old playbook are about to find out what that costs.

Nate and Lior sat down with Mark-David McLaughlin, Head of Security Architecture and Engineering at InterSystems, whose software quietly powers hospitals, health systems, and critical infrastructure worldwide. Mark-David came up through software engineering at Cisco, a decade in PSIRT handling incidents when things went badly wrong, and now leads product security for one of the most sensitive industries on the planet. 

His take on what AI actually changes is grounded in 20+ years of hard lessons, and at least one story that will make you rethink how much you trust your SOC.

Impactful Moments:
00:00 – Introduction
03:00 – Mark-David’s origin story: high school pranks, real consequences
07:00 – How incident response is changing where AI is being introduced
08:00 – We’re losing the architecture review to AI
13:10 – The bad guys will have this new technology in months, act now
17:00 – The SOC model won’t carry us to the future
19:50 – Ransomware, nation-states, and kinetic-cyber fusion
25:30 – If anyone goes onto a web interface in 5 years, we’ve done our jobs wrong
31:00 – How AI almost framed an innocent developer
34:30 – How your team will change as a software architecture company with AI 
41:30 – Why healthcare is uniquely hard to secure
47:30 – Rapid fire questions with Mark-David

Interested in being a guest or want to recommend someone? Reach out to us at [email protected]