Pathocast in Review

Pathocast in Review
Podcast Description
The Pathocast in Review adopts a journal club format to critically dissect the latest research in immunology, virology, and infectious disease. Join our panellist as they deep-dive into recently published studies in a roundtable discussion. Leaving no stone unturned—we cover groundbreaking work across basic science, translational research, and clinical studies that are pushing the boundaries of the field.
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Instagram - instagram.com/pathocast_review
Tiktok - www.tiktok.com/@pathocast_rev
Podcast Insights
Content Themes
The podcast primarily focuses on the latest discoveries in immunology, with episodes covering topics such as targeting precursor B cells for broadly neutralizing antibodies and the unexpected role of antibiotics in HIV prevention for uncircumcised men. Specific discussions highlight groundbreaking research from both basic science and clinical studies that impact global health strategies.

The Pathocast in Review adopts a journal club format to critically dissect the latest research in immunology, virology, and infectious disease. Join our panellist as they deep-dive into recently published studies in a roundtable discussion. Leaving no stone unturned—we cover groundbreaking work across basic science, translational research, and clinical studies that are pushing the boundaries of the field.
follow us on:
Instagram – instagram.com/pathocast_review
Tiktok – www.tiktok.com/@pathocast_rev

Welcome to Pathocast In Review – S1. Ep1: Targeting precursor B Cells for bnAbs | Antibiotics to protect uncircumsed from HIV.
In our premiere episode, we dive into the cutting edge of HIV science. Join us as we explore the latest findings on the quest for an effective HIV vaccine—specifically, how broadly neutralising antibodies are induced by vaccines by targeting extremely rare precursor B cells.
We also unpack new research into how antibiotics might offer an unexpected tool in HIV prevention for men who opt not to undergo circumcision. It’s a nuanced discussion at the intersection of immunology, microbiota, and global health strategy.
Papers in Review:
1. Diverse priming outcomes under conditions of very rare precursor B cells (DOI: 10.1016/j.immuni.2025.03.003).
2. Impact of antimicrobials on penile HIV susceptibility and immunology in uncircumcised men: A randomized phase 1/2 clinical trial (DOI: 10.1016/j.xcrm.2024.101705).
Moderator: Sherazaan Ismail
Panelists: Sonwa Dzanibe (@sonwa_dzanibe) and Adijat Jimoh (@deejah_deej)
Production: Zd Creations
Creator: Immun-Vir JC
Music: iLethu (@Mphephethwa_sa)
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