unNatural Selection
unNatural Selection
Podcast Description
Curious about what innovation looks like in industries vastly different from yours? The unNatural Selection Podcast applies ‘survival of the fittest’ to the world of business innovation. We explore how organizations adapt, evolve, and outcompete under the ruthless laws of evolution. In the podcast, I take a hands-on approach to talk to pioneers across industries to find out how they evolve faster than the competition—and what it really takes to thrive at their frontiers.
Podcast Insights
Content Themes
The podcast focuses on the theme of business innovation across various fields, with episodes exploring diverse topics such as sports psychology in talent development, governmental influence on genomics research, hospitality design strategies, healthcare innovation models, gaming industry transformations, NASA’s leadership in space exploration, and survival strategies in self-defense training. Specific episodes delve into how mentors shape championship mindsets in tennis, the impact of funding cuts on genomics, and the lessons learned from Kodak's resistance to digital innovation.

~ Evolution by Design: Synthesizing Cross-Industry Innovation ~
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Curious about what innovation looks like in industries vastly different from yours? The UnNatural Selection Podcast applies ‘Survival of the Fittest’ to the world of business innovation. We explore how organizations adapt, evolve, and outcompete under the ruthless laws of evolution — directly from the pioneers shaping their frontiers.
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* This podcast is a living thesis on innovation strategy. The best place to start are the Synthesis Episodes (eg Episode 25)
What allows some companies to survive technological revolutions while others disappear?In this episode of UnNatural Selection, host Nic Encina sits down with Sam Schillace — CVP and Deputy CTO at Microsoft, serial entrepreneur, founder of Writely (which became Google Docs), and one of the leading thinkers shaping the future of AI and software platforms.Together, they explore how major platform shifts — from the internet and cloud computing to artificial intelligence — fundamentally reshape competition, organizations, and society itself.This conversation dives into:
- why successful companies struggle to adapt
- how AI is changing the nature of work and software
- the importance of self-disruption
- why speed of learning matters more than size
- startup survival and technological evolution
- the future of intelligence, platforms, and human collaboration
A fascinating conversation about adaptation, innovation, and what it takes to survive when technology changes faster than institutions can evolve.

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