Up One
Up One
Podcast Description
Up One cuts through the noise of health and wellness trends. Hosted by Sawyer Stone and longevity scientist Dr. Bill Andrews, each episode unpacks peer-reviewed research on supplements, therapies, and diagnostics—no fluff, just facts. If you're serious about the science of aging and human performance, it's time to take it Up One.
Podcast Insights
Content Themes
The podcast explores essential themes such as the science of aging, human performance, and evidence-based health interventions. Episodes may cover topics like the efficacy of certain supplements, the latest research on aging therapies, and the implications of diagnostics on health outcomes, with specific examples including analyses of popular anti-aging products and methodologies in health optimization.

Up One cuts through the noise of health and wellness trends. Hosted by Sawyer Stone and longevity scientist Dr. Bill Andrews, each episode unpacks peer-reviewed research on supplements, therapies, and diagnostics – no fluff, just facts. If you’re serious about the science of aging and human performance, it’s time to take it Up One.
Sawyer Stone and Dr. Bill Andrews demystify the complex relationship between mitochondrial health and the aging process. Dr. Bill breaks down cellular energy, explaining how mitochondria function as the body’s primary power source through ATP production. The discussion moves beyond simple marketing hype to explain how short telomeres act as a “dimmer switch” that can shut down mitochondrial efficiency. From the benefits of Urolithin A and NAD precursors to a surprising revelation featuring Dr. Bill’s personal history with Betty White, this episode provides a comprehensive look at how to maintain cellular resilience and why the future of longevity depends on protecting both our batteries and our genetic hard drives!

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