Up One
Up One
Podcast Description
Up One cuts through the noise of health and wellness trends. Hosted by Sawyer Stone and longevity scientist Dr. Bill Andrews, each episode unpacks peer-reviewed research on supplements, therapies, and diagnostics—no fluff, just facts. If you're serious about the science of aging and human performance, it's time to take it Up One.
Podcast Insights
Content Themes
The podcast explores essential themes such as the science of aging, human performance, and evidence-based health interventions. Episodes may cover topics like the efficacy of certain supplements, the latest research on aging therapies, and the implications of diagnostics on health outcomes, with specific examples including analyses of popular anti-aging products and methodologies in health optimization.

Up One cuts through the noise of health and wellness trends. Hosted by Sawyer Stone and longevity scientist Dr. Bill Andrews, each episode unpacks peer-reviewed research on supplements, therapies, and diagnostics – no fluff, just facts. If you’re serious about the science of aging and human performance, it’s time to take it Up One.
In this frank discussion on Up One, host Sawyer Stone is joined by Dr. Bill Andrews and longevity physician Dr. Sandra Kaufmann to demystify menopause, an event Dr. Kaufmann calls “a canary in the coal mine” for a woman’s aging process. They debate the underlying cause, with Dr. Andrews questioning if it’s a random genetic accident linked to ‘Mitochondria Eve’ or a mysterious, non-linear timing mechanism. Dr. Kaufmann offers the view that it’s fundamentally ovarian failure driven by high metabolic demands , and they address common symptoms like osteoporosis, fatigue, and the surprising link between estrogen decline and LDL cholesterol. They also discuss the crucial timing of hormone replacement therapy and the non-linear “cobweb” of interconnected molecular pathways that influence a woman’s transition.
References:
Osteo Strong: https://www.osteostrong.me/
The Kaufmann Protocolhttps://kaufmannprotocol.com/
Follow Dr. Kaufmann on Instagram https://www.instagram.com/kaufmannlongevity/?hl=en
Send Dr. Bill an email! [email protected]

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