In this episode, we spotlight Forum Discussion 06 from the AD/PD™ 2025 International Conference — “Therapy for AD, PD & LBD: Novel Translational Models, New Receptor- and Neuroinflammation-Based Targets – How Close Are We to Success?”

The session was moderated by Prof. Gabriel Gold (Switzerland) and Dr. Meg Smith (USA), with contributions from Dr. Pablo Sardi (USA), Prof. Michael Heneka (Luxembourg), Prof. Thomas Südhof (USA), Dr. Taylor Schmitz (Canada), Prof. Frank Longo (USA), and Dr. Cynthia Lemere (USA).

Key highlights include:

• The ongoing challenge of translating preclinical success into human trials, and the limitations of current animal models

• Efforts to develop more human-relevant models, such as those from the NIH-funded Model AD and Marmoset AD initiatives

• The potential of cross-species omics approaches to improve understanding between mouse and human biology

• Advances in in vitro and organoid models, offering new opportunities to study human-specific neuronal and synaptic functions

• The role of AI and data integration in accelerating drug discovery and identifying novel therapeutic pathways

• Exploration of pathology spread in Alzheimer’s disease, an area poorly represented in traditional models

• Discussion of non-human primate models, highlighting both their translational promise and ethical considerations

• The emergence of neuroinflammation, receptor-based mechanisms, and systemic factors as key therapeutic targets

• Recognition of resilience mechanisms and sex differences in disease progression and response to treatment

This discussion offers a deep dive into the evolving landscape of translational neuroscience, where technology, biology, and innovation intersect to drive new therapeutic possibilities.

Ideal for researchers, clinicians, and industry professionals working in neurodegenerative disease modeling, drug discovery, and translational medicine.

This podcast was created using AI to provide a quick and insightful summary of an AD/PD™ 2025 session. While every effort has been made to ensure accuracy, listeners are encouraged to refer to original conference materials and recordings for detailed information.

The AD/PD™ 2025 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders, took place on April 1-5, 2025, in Vienna Austria.

https://adpd.kenes.com/