Making AI Possible
Making AI Possible
Podcast Description
Welcome to the Making AI Possible Podcast—your new monthly deep dive into the latest breakthroughs in artificial intelligence and how they’re shaping the world around us. Produced at Caltech in Pasadena, California, this series features in-depth conversations with the people driving AI innovation forward.
This podcast series features the latest AI advancements with some of the brightest minds in the field, such as groundbreaking research from AI industry leaders, labs here on campus, and the Jet Propulsion Laboratory (JPL), which Caltech manages for NASA. Discover how cutting-edge research is being applied to transform and streamline healthcare, energy, manufacturing, and finance.
Each episode explores the "how" behind AI breakthroughs and the "why" that drives innovation—from lab to enterprise. Whether you're a technologist, strategist, or decision-maker, Making AI Possible offers rare insight into how advanced AI systems are built, governed, and applied in the real world. Tune in to discover how the latest research becomes transformative technology.
Podcast Insights
Content Themes
The podcast covers a range of topics centered around artificial intelligence, including its applications in healthcare, energy, manufacturing, and finance. For instance, episodes explore how AI innovations from the Jet Propulsion Laboratory are applied in real-world contexts, and discussions around the transformation of decision-making processes in organizations through advanced AI systems.

Welcome to the Making AI Possible Podcast—your new monthly deep dive into the latest breakthroughs in artificial intelligence and how they’re shaping the world around us. Produced at Caltech in Pasadena, California, this series features in-depth conversations with the people driving AI innovation forward.
This podcast series features the latest AI advancements with some of the brightest minds in the field, such as groundbreaking research from AI industry leaders, labs here on campus, and the Jet Propulsion Laboratory (JPL), which Caltech manages for NASA. Discover how cutting-edge research is being applied to transform and streamline healthcare, energy, manufacturing, and finance.
Each episode explores the “how” behind AI breakthroughs and the “why” that drives innovation—from lab to enterprise. Whether you’re a technologist, strategist, or decision-maker, Making AI Possible offers rare insight into how advanced AI systems are built, governed, and applied in the real world. Tune in to discover how the latest research becomes transformative technology.
Welcome to the Making AI Possible Podcast—your monthly deep dive into the latest breakthroughs in artificial intelligence and how they’re shaping the world around us. Produced at Caltech in Pasadena, California, this series features in-depth conversations with the people driving AI innovation forward.
In our third episode of Making AI Possible for Season 2, we present Out of This World Autonomy and AI. Director of AI Programs, Nicholas Beaudoin welcomes guest Issa Nesnas, Principal Robotics Technologist at NASA’s Jet Propulsion Laboratory, whose work spans multiple generations of martian and lunar rovers and foundational autonomy systems.
Together, Nicholas and Issa will explore the harsh realities of operating on planetary bodies, from communication delays and radiation-hardened processors to unpredictable terrain and irreversible mistakes. The conversation digs into:
• how computer vision functions in unknown environments
• how onboard systems make decisions with limited compute
• what “autonomy assurance” really means when a single error can end a mission
This is a look at the engineering discipline required to build AI systems that are bounded, tested, and trusted where failure is permanent.

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