Is Progesterone Only for Women with a Uterus? The Truth About Hormone Therapy

When you hear “progesterone,” do you immediately think it’s only necessary for women who still have a uterus? Think again.

In this episode of The Modern Midlife Collective, Dr. Jillian Woodruff, board-certified gynecologist and menopause specialist, and Dr. Ade Akindipe, functional medicine expert and nurse practitioner, unpack one of the most persistent myths in women’s health: that progesterone is optional after hysterectomy.

Together, they explore why progesterone plays a vital role in hormone therapy far beyond uterine protection. From supporting sleep and reducing anxiety, to protecting the brain, bones, and cardiovascular system, progesterone proves itself to be essential for midlife health. The conversation also breaks down confusing terminology around progesterone vs. progestins, dives into different forms and dosing options, and emphasizes why individualized care is key to safe and effective treatment.

You’ll also hear candid insights on side effects, how hormones work in symphony, and why finding a knowledgeable provider matters when navigating hormone therapy.

✨ You’ll walk away knowing that progesterone’s story is much bigger than just the uterus.

Episode Highlights:

• Why you still need progesterone even without a uterus
• The neuroprotective and anti-inflammatory benefits of progesterone
• Continuous vs. cyclic dosing—what works best and why
• Differences between bioidentical progesterone and synthetic progestins
• How progesterone supports sleep, mood, and hormone balance
• Side effects to be aware of and how to adjust care
• The importance of individualized approaches to hormone therapy

Memorable Quotes:

• “Progesterone’s role does not end with the uterus.”
• “The key is—it’s not a blanket rule.”
• “We have to share the not so good parts too.”

Chapters:
 00:00 Debunking the Uterus Myth
 02:42 The Role of Progesterone in Hormone Therapy
 05:45 Understanding Dosing: Continuous vs. Cyclic Progesterone
 08:34 Progesterone’s Neuroprotective Benefits
 11:39 The Importance of Progesterone for Bone and Cardiovascular Health
 14:34 Clarifying Terminology: Progesterone vs. Progestins
 17:30 Forms of Progesterone: Oral, Vaginal, and Topical
 20:04 Dosing Guidelines for Hormone Replacement Therapy
 23:01 Potential Side Effects and Considerations
 25:42 Individualized Care in Hormone Therapy

Meet Your Hosts:

Dr. Ade Akindipe, DNP, MBA, APRN, FNP-C

A board-certified nurse practitioner and founder of Rejuvenate Health & Wellness, Dr. Akindipe specializes in hormone and obesity medicine with a focus on root-cause, functional approaches. He is an advocate for health equity and serves as Co-Chair of the Health Committee for the Alaska Black Caucus, working to expand access to preventive care for underserved communities.

Dr. Jillian Woodruff, MD, FACOG, NCMP
A board-certified gynecologist and nationally certified menopause practitioner, Dr. Woodruff is the Chief Medical Officer of Modern Gynecology & Skin. She is also host of NPR-affiliated Line One on Alaska Public Media and co-founder of The Women’s WELL Foundation. Her expertise spans hormone therapy, sexual wellness, and aesthetic medicine, empowering women to lead vibrant, informed lives.

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