High5 with Dr. Igor Grant, MD
High5 with Dr. Igor Grant, MD
Podcast Description
Welcome to High5 with Dr. Igor Grant, Distinguished Professor of Psychiatry and Director of the Center for Medicinal Cannabis Research at UC San Diego. Each month, we’ll take you on a fascinating journey into the evolving world of medicinal cannabis. From groundbreaking research to candid conversations with top scientists and clinicians across the globe. In each episode, Dr. Grant poses five thought-provoking questions to his guest, uncovering their personal journey and unique contributions to the field of medicinal cannabis.
Podcast Insights
Content Themes
The podcast delves into various topics surrounding medicinal cannabis, including its impact on pain management, the role of neuroimaging in understanding substance use, and cardiovascular risks associated with cannabis use, with specific episodes discussing the Cannabis Act in Canada and its implications for the U.S. as well as the relationship between cannabis and driving impairment.

Welcome to High5 with Dr. Igor Grant, Distinguished Professor of Psychiatry and Director of the Center for Medicinal Cannabis Research at UC San Diego. Each month, we’ll take you on a fascinating journey into the evolving world of medicinal cannabis. From groundbreaking research to candid conversations with top scientists and clinicians across the globe. In each episode, Dr. Grant poses five thought-provoking questions to his guest, uncovering their personal journey and unique contributions to the field of medicinal cannabis.
In this episode, Dr. Deepak D'Souza, a renowned psychiatrist from Yale University, discusses the complex relationship between cannabis and psychosis. He explores the potential causal links, the role of environmental factors, and the implications of cannabis-induced psychosis as a precursor to schizophrenia. The conversation delves into the evolving landscape of cannabis potency and its impact on mental health, drawing parallels with historical public health challenges like smoking and lung cancer.
Takeaways
• Cannabis can induce transient psychotic symptoms during intoxication.
• Cannabis-induced psychosis may be a precursor to schizophrenia.
• Environmental factors, like cannabis use, can impact schizophrenia risk.
• Cannabis potency has increased, affecting psychosis rates.
• Cannabis is a modifiable risk factor for mental health disorders.
• Not everyone who uses cannabis develops psychosis.
• Cannabis use during adolescence may increase schizophrenia risk.
• Genetic predisposition plays a role in cannabis-related psychosis.
• Cannabis and schizophrenia have a complex, multifactorial relationship.
• Preventing cannabis use in youth could reduce schizophrenia cases.
Chapters
00:00 – Intro
01:19 – Professional Background – Deepak Cyril D'Souza
02:29 – Understanding Psychosis and Cannabis
03:15 – Background on Schizophrenia
05:06 – Symptoms of Psychosis vs. Psychotic Disorders, Causality
10:31 – Cannabis Induced Psychosis
12:28 – Causality: Cannabis and Schizophrenia | The Bradford Hill Criteria for Causality
23:20 – The Role of Genetics and Environment
29:30 – Risk Factors Associated with Schizophrenia
32:29 – Advice for Healthcare Providers and Families

Disclaimer
This podcast’s information is provided for general reference and was obtained from publicly accessible sources. The Podcast Collaborative neither produces nor verifies the content, accuracy, or suitability of this podcast. Views and opinions belong solely to the podcast creators and guests.
For a complete disclaimer, please see our Full Disclaimer on the archive page. The Podcast Collaborative bears no responsibility for the podcast’s themes, language, or overall content. Listener discretion is advised. Read our Terms of Use and Privacy Policy for more details.