-Title: Advancing Patient Monitoring, Diagnostics, and Treatment Strategies for Transplant Precision Medicine

This is part two in a three-part webinar series based on recent Clinical Series publications in The Lancet on Solid Organ Transplantation:
🔗 https://www.thelancet.com/series-do/o…

This webinar series is a collaboration between The Lancet, The Transplantation Society (TTS), the American Society of Transplantation (AST), and the European Society for Organ Transplantation (ESOT).

Featuring:
Jennifer Li (Chair), Australia – TTS Education Co-Chair
Peter Reese (Organizer), United States
Marta Sablik (Panelist), France
Alexandre Loupy (Panelist), France

Overview:
Transplant medicine faces substantial challenges, as patients require lifelong immunosuppression to prevent graft rejection. Immunosuppressive regimens to date, while reasonably effective at preventing acute rejection, cause numerous health complications, compromising quality of life and patient survival. A shift towards personalised immunosuppression is needed to improve allograft health, reduce long-term adverse effects, and optimise post- transplant outcomes. This necessity has driven advancements in post-transplant monitoring and diagnostics. Innovative monitoring biomarkers and novel diagnostic modalities have been developed to advance transplant care, with many showing promise for widespread clinical implementation. With advances in artificial intelligence, algorithms have the potential to integrate multidimensional data on the immune system and allograft health, offering a comprehensive view of transplant status. This Series paper highlights the state of post-transplant immunosuppression, monitoring, and diagnostics, emphasising the transformative role of emerging innovations to personalise both allograft and patient care. Their implications could extend to xenotransplantation, further broadening their potential to redefine transplant medicine.

Learning Objectives:
– Understand the current challenges and limitations associated with lifelong immunosuppression in transplant recipients
– Have an overview of the recent advancements in post-transplant monitoring tools and diagnostic biomarkers, with a focus on their clinical potential for personalizing immunosuppressive regimens
– Outline future research priorities necessary to validate, standardize, and implement innovative diagnostic strategies in routine transplant clinical practice
– Outline the emerging role of artificial intelligence in transplant medicine, including how it may be used to integrate complex immunological and clinical data to enhance graft monitoring and decision-making

For more information visit the 🔗 Webinar Homepage: https://tts.org/lancet1

About the Series:
Solid organ transplantation offers tremendous benefits for patients with end-stage organ disease. However, key challenges persist: organ shortages, immunosuppression-related toxicities, and inequities in access.
This Lancet Clinical Series explores opportunities to address these issues:

Upcoming Webinars:

Part 1 – July 7, 2025
Scientific Advances in the Assessment, Modification, and Generation of Transplantable Organs for Patients with End-stage Organ Diseases
View recording: https://tts.org/lancet1

Part 3 – July 25, 2025
Policy Innovations to Advance Equity in Solid Organ Transplantation
More details and registration: https://tts.org/lancet3