🎙️ Hosts: Erin Hubbard and Laurel Gregier

🎤 Guest: Dr. Angela Martin

📅 Release Date: 4/8/2025

🔬 Topic: Understanding Beta-Mannosidosis and the Innovation Behind Enzyme Replacement Therapy

Episode Overview

In this episode of These Kids Can’t Wait, hosts Erin Hubbard and Laurel Gregier are joined by Dr. Angela Martin, a postdoctoral researcher at the Kimonis Laboratory and a vital force in The Lost Enzyme Project. Together, we discuss beta-mannosidosis, a rare lysosomal storage disorder, and the innovative efforts underway to develop treatments, including a promising new therapy using J-Brain Cargo technology.

Key Takeaways

✔️ What beta-mannosidosis is and why it’s so difficult to diagnose and treat

✔️ How J-Brain Cargo technology enables enzyme delivery across the blood-brain barrier

✔️ The stages of drug development—from lab to clinical trials

✔️ Why underdiagnosis is a major issue for ultra-rare diseases

✔️ The power of international collaboration in rare disease innovation

Resources & Links

🌐 Learn more: thelostenzymeproject.org

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https://www.facebook.com/people/The-Lost-Enzyme-Project/61551541563692/

📩 Contact us:

Email us at [email protected]

Producer: [email protected]

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