Demystifying PANS/PANDAS Podcast
Demystifying PANS/PANDAS Podcast
Podcast Description
Welcome to the Demystifying PANS/PANDAS Podcast with Dr. Nancy O'Hara! Ever wondered why some kids experience sudden, life-altering behavioral changes? This podcast delves into PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) and PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Strep). Experts explore the triggers, symptoms, and innovative treatments for these autoimmune disorders, blending science and heartfelt guidance. From strep to Lyme, natural therapies, emotional support, and recovery stories—this is your guide to hope and healing.
Podcast Insights
Content Themes
The podcast primarily focuses on PANS and PANDAS, covering topics such as the science behind these conditions, symptoms, treatment options, and personal recovery stories. Episodes include expert interviews explaining causes like strep and Lyme, discussions on natural therapies, and practical advice for parents and caregivers navigating the challenges of these disorders.

Welcome to the Demystifying PANS/PANDAS Podcast with Dr. Nancy O’Hara! Ever wondered why some kids experience sudden, life-altering behavioral changes? This podcast delves into PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) and PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Strep). Experts explore the triggers, symptoms, and innovative treatments for these autoimmune disorders, blending science and heartfelt guidance. From strep to Lyme, natural therapies, emotional support, and recovery stories—this is your guide to hope and healing.
At ReligenDX, we are revolutionizing diagnostic testing by equipping healthcare professionals with cutting-edge tools for early detection, targeted interventions, and improved patient outcomes. Our innovative solutions, including the Folate Receptor Antibody Test (FRAT) for PANS, PANDAS, and Autism, provide critical insights into neurological and immune-related conditions. With a commitment to scientific excellence and personalized medicine, ReligenDX empowers clinicians to make informed decisions and optimize treatment for every patient.
Website: fratnow.com or religendx.com
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Normal folate test results may not tell you what the brain actually needs. In this episode of Demystifying PANS/PANDAS, Dr. Richard Frye, a child neurologist, joins us to explain cerebral folate deficiency, why many kids show brain-level need despite normal blood tests, and how targeted folinic acid, dairy elimination, and mitochondrial support can unlock language, calm tics, and steady behavior.
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Think your child’s folate levels are fine? Here’s why that test might be lying to you. In this episode of Demystifying PANS/PANDAS, Dr. Richard Frye shares the fascinating story behind cerebral folate deficiency, how antibodies can block folate from entering the brain, and why so many kids with autism improve with folinic acid (leucovorin). He explains how symptoms shift with age and why some children need more folate, not less.
Dr. Frye then reveals surprising connections: how dairy proteins can block receptors, why certain brands of leucovorin work better, and why ‘normal’ folate tests often mislead. He connects mitochondrial overdrive, nutrient gaps, and prenatal stress, showing parents and practitioners how a step-by-step plan helps children regain focus, energy, and progress.
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Dr. Richard Frye is a Child Neurologist with expertise in neurodevelopmental and neurometabolic disorders. He received an MD and PhD in Physiology and Biophysics from Georgetown University. He completed a residency in Pediatrics at the University of Miami, Residency in Child Neurology and Fellowship in Behavioral Neurology and Learning Disabilities at Harvard University/Children’s Hospital Boston and Fellowship in Psychology at Boston University. He also received a Masters in Biomedical Science and Biostatistics from Drexel University. He holds board certifications in Pediatrics, and in Neurology with Special Competence in Child Neurology. He has authored over 300 publications and book chapters and serves on several editorial boards.
Dr. Frye is a national leader in autism spectrum disorder (ASD) research. He is President and Chief Scientific Officer of the Autism Discovery and Treatment Foundation, Chief Medical Officer of the Neurological Health Foundation, Director of Research and Neurologist at the Rossignol Medical Center and Principal Investigator at the Southwest Autism Research and Resource Center.
He has lead several clinical studies on children with ASD, including studies focusing on defining the clinical, behavioral, cognitive, genetic and metabolic characteristics of children with ASD and mitochondrial disease and several clinical trials demonstrating the efficacy of safe and novel treatments that target underlying physiological abnormalities in children with ASD, including studies on leucovorin, cobalamin and tetrahydrobiopterin and has an ongoing multicenter controlled clinical trial on leucovorin, neuroimmune modulators and photobiomodulation.
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Nancy O’Hara, MD, MPH, FAAP, FMAPS
Website:https://www.drohara.com
Facebook:https://www.facebook.com/drnancyohara/
Instagram:https://www.instagram.com/nhoharamd/
LinkedIn:https://www.linkedin.com/in/nancy-o-hara-md-mph-faap-390781258/
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