Cholestatic Pruritus Associated with PBC: Understanding Unmet Patient Needs and Treatment Strategies
Cholestatic Pruritus Associated with PBC: Understanding Unmet Patient Needs and Treatment Strategies
Podcast Description
Pruritus occurs in up to 70% of patients with primary biliary cholangitis (PBC), can be severe, and lead to increased morbidity-including worsening fatigue and quality of sleep. Standard of care treatment has relied on a variety of medications with limited effectiveness and tolerability adding to the patient disease burden. Alan Bonder, MD, and Kris Kowdley, MD, discuss unmet patient needs, pruritus assessment tools, and guideline-based therapy provided by an interprofessional care team.
Podcast Insights
Content Themes
The podcast covers critical themes related to the symptoms and management of PBC, including pruritus assessment tools, treatment options, and guideline-based care strategies. Episodes specifically dive into the exploration of investigational therapies like IBAT inhibitors and PPAR agonists, addressing unmet patient needs and the importance of interprofessional collaboration.
Pruritus occurs in up to 70% of patients with primary biliary cholangitis (PBC), can be severe, and lead to increased morbidity-including worsening fatigue and quality of sleep. Standard of care treatment has relied on a variety of medications with limited effectiveness and tolerability adding to the patient disease burden. Alan Bonder, MD, and Kris Kowdley, MD, discuss unmet patient needs, pruritus assessment tools, and guideline-based therapy provided by an interprofessional care team.
Alan Bonder, MD, and Kris Kowdley, MD, discuss unmet patient needs, pruritus assessment tools, and guideline-based therapy provided by an interprofessional care team. They also explore safety and efficacy data from trials of emerging treatment options including ileal bile acid transporter (IBAT) inhibitors and peroxisome proliferator-activated receptor (PPAR) agonists.
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