Reflecting on his subpar Manchester Marathon performance, Matthew draws lessons for clinical trials and business strategy. He underscores the importance of controlling known factors while preparing for unknown challenges. Key strategies include meticulous planning, setting controllable metrics, and developing mental resilience based on the ‘Chimp Paradox’ to manage emotional responses. By translating the discipline of marathon training into business processes, individuals can better achieve their goals, even amidst adversity, through the power of communication, standard setting, and adaptability.