To Immunity and Beyond
To Immunity and Beyond
Podcast Description
In a series produced by the Oxford Immunology Network, Professor Paul Klenerman talks with colleagues about their recent ground-breaking publications, exploring the original scientific goals, challenges they encountered along the way, and future ambitions in the field. This series will be of interest to anyone studying or working in immunology, medical sciences, biology or related fields.
NB: To Immunity and Beyond is for educational purposes only and should not be considered professional medical advice.
Podcast Insights
Content Themes
The series centers on pivotal themes in immunology, medical sciences, and biology, exploring current research advancements. Specific episode examples include discussions on CAR-T cell sensitivity engineering, the role of ADAM10 in T cell efferocytosis, and genetic risks for multiple sclerosis in historical populations, presenting foundational studies and their implications for future research.
In a series produced by the Oxford Immunology Network, Professor Paul Klenerman talks with colleagues about their recent ground-breaking publications, exploring the original scientific goals, challenges they encountered along the way, and future ambitions in the field. This series will be of interest to anyone studying or working in immunology, medical sciences, biology or related fields.
NB: To Immunity and Beyond is for educational purposes only and should not be considered professional medical advice.
A conversation with Fadi Issa about his recent article on regulatory T cell therapy in kidney transplants. In this episode of To Immunity and Beyond, Paul Klenerman talks with surgeon and immunologist Fadi Issa about pioneering regulatory T-cell therapy in kidney transplantation. Fadi shares his journey from reconstructive surgery to immune tolerance research and discusses the groundbreaking, first-in-human ONE Trial of T reg therapy in kidney transplantation. The trial showed promising graft survival rates, and found B cell-enriched focal lymphocytic infiltrates in the T reg treated group. Paul and Fadi also explore how current work with spatial transcriptomics will enable further insights into this mechanism.
Full article: Oliver McCallion, Amy R. Cross, Matthew O. Brook, Conor Hennessy, Ricardo Ferreira, Dominik Trzupek, William R. Mulley, Sandeep Kumar, Maria Soares, Ian S. Roberts, Peter J. Friend, Giovanna Lombardi, Kathryn J. Wood, Paul N. Harden, Joanna Hester, Fadi Issa, Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants, Med, Volume 6, Issue 5, 2025, 100561, ISSN 2666-6340, https://doi.org/10.1016/j.medj.2024.11.014.
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