To Immunity and Beyond

To Immunity and Beyond
Podcast Description
In a series produced by the Oxford Immunology Network, Professor Paul Klenerman talks with colleagues about their recent ground-breaking publications, exploring the original scientific goals, challenges they encountered along the way, and future ambitions in the field. This series will be of interest to anyone studying or working in immunology, medical sciences, biology or related fields.
NB: To Immunity and Beyond is for educational purposes only and should not be considered professional medical advice.
Podcast Insights
Content Themes
The series centers on pivotal themes in immunology, medical sciences, and biology, exploring current research advancements. Specific episode examples include discussions on CAR-T cell sensitivity engineering, the role of ADAM10 in T cell efferocytosis, and genetic risks for multiple sclerosis in historical populations, presenting foundational studies and their implications for future research.

In a series produced by the Oxford Immunology Network, Professor Paul Klenerman talks with colleagues about their recent ground-breaking publications, exploring the original scientific goals, challenges they encountered along the way, and future ambitions in the field. This series will be of interest to anyone studying or working in immunology, medical sciences, biology or related fields.
NB: To Immunity and Beyond is for educational purposes only and should not be considered professional medical advice.
Dr Kirsty McHugh and Dr Carolyn Nielsen discuss a recent Cell article: ‘Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype’. This episode discusses the following article: Barrett, J et al., Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype. Cell 187 (5 September 2024). https://doi.org/10.1016/j.cell.2024.06.015
Article funding and acknowledgments: https://www.sciencedirect.com/science/article/pii/S009286742400655X?via%3Dihub#ack0010
The paper discussed in this episode is the product of six years of work with important contributions made by many members of Prof Simon Draper’s blood-stage malaria team, as well as key external collaborators. Dr McHugh and Dr Nielsen would like to thank all authors for their input, in particular Jordan Barrett as first author, Dimitra Pipini for antibody expression, Giacomo Gorini as the early phase project lead, Nathan Wright for the structural work, and Brandon Wilder for the mouse model. USAID was the major funder.
Full author list:
Jordan R Barrett, Dimitra Pipini, Nathan D Wright, Andrew J R Cooper, Giacomo Gorini, Doris Quinkert, Amelia M Lias, Hannah Davies, Cassandra A Rigby, Maya Aleshnick, Barnabas G Williams, William J Bradshaw, Neil G Paterson, Thomas Martinson, Payton Kirtley, Luc Picard, Christine D Wiggins, Francesca R Donnellan, Lloyd D W King, Lawrence T Wang, Jonathan F Popplewell, Sarah E Silk, Jed de Ruiter Swain, Katherine Skinner, Vinayaka Kotraiah, Amy R Noe, Randall S MacGill, C Richter King, Ashley J Birkett, Lorraine A Soisson, Angela M Minassian, Douglas A Lauffenburger, Kazutoyo Miura, Carole A Long, Brandon K Wilder, Lizbé Koekemoer, Joshua Tan, Carolyn M Nielsen, Kirsty McHugh* and Simon J Draper*.
*Joint senior authors.

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