Journal Club Archives – Cardionerds
Journal Club Archives - Cardionerds
Podcast Description
A cardiology platform that aims to democratized cardiovascular education
Podcast Insights
Content Themes
CardioNerds focuses on a range of cardiovascular education topics, with episodes dedicated to recent clinical trial discussions, risk factor management, heart failure treatments, and innovative therapies like CRISPR. For example, episodes like 'The ARREST-AF Trial' examine intensive risk factor management strategies, while 'The SUMMIT Trial' focuses on the effects of tirzepatide in heart failure patients.
A cardiology platform that aims to democratized cardiovascular education
Dr. Jeanne De Lavallaz and Dr. Ramy Doss discuss the results of the TRANSFORM-AF Trial with expert faculty Dr. Sanjeev Saksena and Dr. Varun Sundaram.
The TRANSFORM-AF trial enrolled 2,510 patients with atrial fibrillation (AF), type 2 diabetes, and obesity across 170 Veterans Affairs hospitals to evaluate the impact of diabetes-dose GLP-1 receptor agonists on AF-related outcomes. Participants were assigned to receive either a GLP-1 receptor agonist, a DPP-IV inhibitor, or a sulfonylurea. The primary composite outcome included AF-related hospitalizations, cardioversions, ablation procedures, and all-cause mortality. Over a median follow-up of 3.2 years, GLP-1 use was associated with a 13% reduction in major AF-related events compared to other therapies. The study population was predominantly male, with a high prevalence of severe obesity (BMI >40 kg/m²) in whom the benefit appeared most pronounced. Notably, the observed benefit occurred despite only modest additional weight loss, suggesting potential non-weight-mediated effects of GLP-1 therapy
This episode was planned in collaboration with Heart Rhythm TV with mentorship from Dr. Daniel Alyesh and Dr. Mehak Dhande.
Join Us at American Heart Association’s Scientific Sessions 2025!
Don’t miss one of the biggest cardiovascular meetings of the year — AHA Scientific Sessions 2025!
📅 November 7–10, 2025
📍 New Orleans, LA
This is your chance to connect with colleagues, hear the latest cutting-edge science, and be part of the conversation shaping the future of cardiovascular care.
👉 Register now and join us in New Orleans!
US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here.
Disclaimer
This podcast’s information is provided for general reference and was obtained from publicly accessible sources. The Podcast Collaborative neither produces nor verifies the content, accuracy, or suitability of this podcast. Views and opinions belong solely to the podcast creators and guests.
For a complete disclaimer, please see our Full Disclaimer on the archive page. The Podcast Collaborative bears no responsibility for the podcast’s themes, language, or overall content. Listener discretion is advised. Read our Terms of Use and Privacy Policy for more details.