SEMS Podcast
SEMS Podcast
Podcast Description
Welcome to the SEMS Podcast! We are a Singapore-based podcast, and we aim to provide a platform for emergency medicine updates and education as well as inter-hospital sharing of medical knowledge and experiences. Episodes will be published twice a month, tune in and follow us to be notified of new episodes!
Podcast Insights
Content Themes
The podcast covers a variety of themes including emergency medicine education, toxicology, and medical guidelines, with episodes like the 'Teaching Effectively on Shift' focusing on instructional strategies, and 'Introduction to Toxicology & Methemoglobinemia' providing insights into specific toxicological cases and management. Other episodes dissect clinical practices, such as the SAEM GRACE-3 Giddiness Guidelines, ensuring listeners stay current with best practices.
Welcome to the SEMS Podcast! We are a Singapore-based podcast, and we aim to provide a platform for emergency medicine updates and education as well as inter-hospital sharing of medical knowledge and experiences. Episodes will be published once or twice a month, tune in and follow us to be notified of new episodes!
In this episode, Elizabeth and Matthew discuss Paracetamol Toxicity with Dr Ng Mingwei. We cover the 2 Bag versus 3 Bag regimens, when to stop NAC, RSTI, what to do for anaphylactoid reactions, massive paracetamol OD, and the paracetamol multiplication product.
Timestamps
01:57 Case #1
03:01 Mechanism of Toxicity
04:00 Risk profiling and Rumack-Matthew Nomogram
06:20 Case #2
08.25: NAC/ 2 bag vs 3 bag regimen
11:24 Paracetamol Guidelines
12:56 Paracetamol Multiplication Product*
*Note: The study quoted was in a population treated with NAC.
14:53 Anaphylactoid reactions
15:37 When to cease NAC
16:24 RSTI
18:04 Massive Paracetamol OD
19:58 Liver transplant
20:47 3 Takeaways
Thank you for listening!
Credits
Music: Life-line by Colorful Sound via Pixabay
SGH Podcast Studio
SEMS
Dr Mong Rupeng for reviewing this episode
References
- Chiew AL, Reith D, Pomerleau A, Wong A, Isoardi KZ, Soderstrom J, Buckley NA. Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand. Med J Aust. 2020 Mar;212(4):175-183. doi: 10.5694/mja2.50428. Epub 2019 Dec 1. PMID: 31786822.
- Wong A, Isbister G, McNulty R, Isoardi K, Harris K, Chiew A, Greene S, Gunja N, Buckley N, Page C, Graudins A. Efficacy of a two bag acetylcysteine regimen to treat paracetamol overdose (2NAC study). EClinicalMedicine. 2020 Mar 19;20:100288. doi: 10.1016/j.eclinm.2020.100288. PMID: 32211597
- Wong A, Sivilotti MLA, Graudins A. Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose. Clin Toxicol (Phila). 2017 Jun;55(5):346-351. doi: 10.1080/15563650.2017.1290253. Epub 2017 Feb 15. PMID: 28421844.
All recordings should not be taken by users/ audience as medical advice. Everyone is encouraged to see their physicians for proper medical consultation.
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